kpt 9274 Search Results


kpt 9274  (MedChemExpress)
93
MedChemExpress kpt 9274
Kpt 9274, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kpt+9274/Padnarsertib/pmc11394300-90-0-7
Average 93 stars, based on 1 article reviews
kpt 9274 - by Bioz Stars, 2026-09
93/100 stars
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kpt-9274  (MuseChem Chemicals)
N/A
PAK4-IN-1 (Cat.No:I002149) is a small molecule inhibitor that targets P21-activated kinase 4 (PAK4), a protein involved in cell signaling pathways. PAK4-IN-1 has shown potential in preclinical studies for its ability to suppress tumor growth, migration,
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pf3758309  (Selleck Chemicals)
93
Selleck Chemicals pf3758309
a–c, ECs isolated from normal human brain or human GBM tumor were treated with the PAK4 inhibitor KPT9274 (0.1–1 μM), the pan-PAK inhibitor <t>PF3758309</t> (1 μM) or 0.1% dimethyl sulfoxide (control). The cells were then subjected to cell viability analysis. a,b, Cell viability of normal ECs (a) and GBM ECs (b) treated with KPT9274 (n = 3 EC samples, each derived from a distinct human GBM tumor; means ± s.e.m.). Statistical significance was determined by two-tailed Student’s t-test (a) or one-way ANOVA (b). c, Cell viability of normal and GBM ECs treated with PF3758309 (n = 3 independent experiments; means ± s.e.m.). Statistical significance was determined by two-way ANOVA. d–g, GBM was induced in Rosa-LSL-tdTomato;Cdh5-CreETR2 mice, followed by treatment with saline, KPT9274 (e and f) or PF3758309 (g). d, Experimental approach. e, Tumors were imaged by light sheet microscopy, followed by three-dimensional reconstruction (n = 3 mice). Each grid, 100 μm. f, Whole tumor tissues were stained with an anti-pimonidazole adduct (hypoxia probe) antibody, followed by light sheet fluorescence imaging. Representative images are shown (n = 3 mice). Scale bars, 150 μm. g, Tumor sections were stained with anti-tdTomato and anti-CD31 antibodies, followed by immunofluorescence analysis. Representative images are shown (n = 3 mice). Scale bar, 100 μm.
Pf3758309, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kpt+9274/KPT+9274/pmc10097424-515-6-7
Average 93 stars, based on 1 article reviews
pf3758309 - by Bioz Stars, 2026-09
93/100 stars
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kpt-9274  (Karyopharm inc)
90
Karyopharm inc kpt-9274
a–c, ECs isolated from normal human brain or human GBM tumor were treated with the PAK4 inhibitor KPT9274 (0.1–1 μM), the pan-PAK inhibitor <t>PF3758309</t> (1 μM) or 0.1% dimethyl sulfoxide (control). The cells were then subjected to cell viability analysis. a,b, Cell viability of normal ECs (a) and GBM ECs (b) treated with KPT9274 (n = 3 EC samples, each derived from a distinct human GBM tumor; means ± s.e.m.). Statistical significance was determined by two-tailed Student’s t-test (a) or one-way ANOVA (b). c, Cell viability of normal and GBM ECs treated with PF3758309 (n = 3 independent experiments; means ± s.e.m.). Statistical significance was determined by two-way ANOVA. d–g, GBM was induced in Rosa-LSL-tdTomato;Cdh5-CreETR2 mice, followed by treatment with saline, KPT9274 (e and f) or PF3758309 (g). d, Experimental approach. e, Tumors were imaged by light sheet microscopy, followed by three-dimensional reconstruction (n = 3 mice). Each grid, 100 μm. f, Whole tumor tissues were stained with an anti-pimonidazole adduct (hypoxia probe) antibody, followed by light sheet fluorescence imaging. Representative images are shown (n = 3 mice). Scale bars, 150 μm. g, Tumor sections were stained with anti-tdTomato and anti-CD31 antibodies, followed by immunofluorescence analysis. Representative images are shown (n = 3 mice). Scale bar, 100 μm.
Kpt 9274, supplied by Karyopharm inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kpt+9274/kpt+9274/pm36731340-79-3-7
Average 90 stars, based on 1 article reviews
kpt-9274 - by Bioz Stars, 2026-09
90/100 stars
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kpt-9274 cs-5146  (ChemScene llc)
90
ChemScene llc kpt-9274 cs-5146
a–c, ECs isolated from normal human brain or human GBM tumor were treated with the PAK4 inhibitor KPT9274 (0.1–1 μM), the pan-PAK inhibitor <t>PF3758309</t> (1 μM) or 0.1% dimethyl sulfoxide (control). The cells were then subjected to cell viability analysis. a,b, Cell viability of normal ECs (a) and GBM ECs (b) treated with KPT9274 (n = 3 EC samples, each derived from a distinct human GBM tumor; means ± s.e.m.). Statistical significance was determined by two-tailed Student’s t-test (a) or one-way ANOVA (b). c, Cell viability of normal and GBM ECs treated with PF3758309 (n = 3 independent experiments; means ± s.e.m.). Statistical significance was determined by two-way ANOVA. d–g, GBM was induced in Rosa-LSL-tdTomato;Cdh5-CreETR2 mice, followed by treatment with saline, KPT9274 (e and f) or PF3758309 (g). d, Experimental approach. e, Tumors were imaged by light sheet microscopy, followed by three-dimensional reconstruction (n = 3 mice). Each grid, 100 μm. f, Whole tumor tissues were stained with an anti-pimonidazole adduct (hypoxia probe) antibody, followed by light sheet fluorescence imaging. Representative images are shown (n = 3 mice). Scale bars, 150 μm. g, Tumor sections were stained with anti-tdTomato and anti-CD31 antibodies, followed by immunofluorescence analysis. Representative images are shown (n = 3 mice). Scale bar, 100 μm.
Kpt 9274 Cs 5146, supplied by ChemScene llc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kpt+9274/kpt+9274+cs+5146/pm37771778-299-15-17
Average 90 stars, based on 1 article reviews
kpt-9274 cs-5146 - by Bioz Stars, 2026-09
90/100 stars
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kpt 9274  (Molecular Dynamics Inc)
86
Molecular Dynamics Inc kpt 9274
a–c, ECs isolated from normal human brain or human GBM tumor were treated with the PAK4 inhibitor KPT9274 (0.1–1 μM), the pan-PAK inhibitor <t>PF3758309</t> (1 μM) or 0.1% dimethyl sulfoxide (control). The cells were then subjected to cell viability analysis. a,b, Cell viability of normal ECs (a) and GBM ECs (b) treated with KPT9274 (n = 3 EC samples, each derived from a distinct human GBM tumor; means ± s.e.m.). Statistical significance was determined by two-tailed Student’s t-test (a) or one-way ANOVA (b). c, Cell viability of normal and GBM ECs treated with PF3758309 (n = 3 independent experiments; means ± s.e.m.). Statistical significance was determined by two-way ANOVA. d–g, GBM was induced in Rosa-LSL-tdTomato;Cdh5-CreETR2 mice, followed by treatment with saline, KPT9274 (e and f) or PF3758309 (g). d, Experimental approach. e, Tumors were imaged by light sheet microscopy, followed by three-dimensional reconstruction (n = 3 mice). Each grid, 100 μm. f, Whole tumor tissues were stained with an anti-pimonidazole adduct (hypoxia probe) antibody, followed by light sheet fluorescence imaging. Representative images are shown (n = 3 mice). Scale bars, 150 μm. g, Tumor sections were stained with anti-tdTomato and anti-CD31 antibodies, followed by immunofluorescence analysis. Representative images are shown (n = 3 mice). Scale bar, 100 μm.
Kpt 9274, supplied by Molecular Dynamics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/kpt+9274/9274+kpt/pm41663153-398-15-0
Average 86 stars, based on 1 article reviews
kpt 9274 - by Bioz Stars, 2026-09
86/100 stars
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kpt 9274  (Biosynth Carbosynth)
N/A
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kpt 9274 ( atg-019)  (Aladdin Scientific Corporation)
N/A
InformationKPT 9274 ( ATG-019) KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT . It shows an IC50 of ~120 nM for NAMPT in
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a–c, ECs isolated from normal human brain or human GBM tumor were treated with the PAK4 inhibitor KPT9274 (0.1–1 μM), the pan-PAK inhibitor PF3758309 (1 μM) or 0.1% dimethyl sulfoxide (control). The cells were then subjected to cell viability analysis. a,b, Cell viability of normal ECs (a) and GBM ECs (b) treated with KPT9274 (n = 3 EC samples, each derived from a distinct human GBM tumor; means ± s.e.m.). Statistical significance was determined by two-tailed Student’s t-test (a) or one-way ANOVA (b). c, Cell viability of normal and GBM ECs treated with PF3758309 (n = 3 independent experiments; means ± s.e.m.). Statistical significance was determined by two-way ANOVA. d–g, GBM was induced in Rosa-LSL-tdTomato;Cdh5-CreETR2 mice, followed by treatment with saline, KPT9274 (e and f) or PF3758309 (g). d, Experimental approach. e, Tumors were imaged by light sheet microscopy, followed by three-dimensional reconstruction (n = 3 mice). Each grid, 100 μm. f, Whole tumor tissues were stained with an anti-pimonidazole adduct (hypoxia probe) antibody, followed by light sheet fluorescence imaging. Representative images are shown (n = 3 mice). Scale bars, 150 μm. g, Tumor sections were stained with anti-tdTomato and anti-CD31 antibodies, followed by immunofluorescence analysis. Representative images are shown (n = 3 mice). Scale bar, 100 μm.

Journal: Nature cancer

Article Title: Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma

doi: 10.1038/s43018-020-00147-8

Figure Lengend Snippet: a–c, ECs isolated from normal human brain or human GBM tumor were treated with the PAK4 inhibitor KPT9274 (0.1–1 μM), the pan-PAK inhibitor PF3758309 (1 μM) or 0.1% dimethyl sulfoxide (control). The cells were then subjected to cell viability analysis. a,b, Cell viability of normal ECs (a) and GBM ECs (b) treated with KPT9274 (n = 3 EC samples, each derived from a distinct human GBM tumor; means ± s.e.m.). Statistical significance was determined by two-tailed Student’s t-test (a) or one-way ANOVA (b). c, Cell viability of normal and GBM ECs treated with PF3758309 (n = 3 independent experiments; means ± s.e.m.). Statistical significance was determined by two-way ANOVA. d–g, GBM was induced in Rosa-LSL-tdTomato;Cdh5-CreETR2 mice, followed by treatment with saline, KPT9274 (e and f) or PF3758309 (g). d, Experimental approach. e, Tumors were imaged by light sheet microscopy, followed by three-dimensional reconstruction (n = 3 mice). Each grid, 100 μm. f, Whole tumor tissues were stained with an anti-pimonidazole adduct (hypoxia probe) antibody, followed by light sheet fluorescence imaging. Representative images are shown (n = 3 mice). Scale bars, 150 μm. g, Tumor sections were stained with anti-tdTomato and anti-CD31 antibodies, followed by immunofluorescence analysis. Representative images are shown (n = 3 mice). Scale bar, 100 μm.

Article Snippet: Cells were treated with KPT9274 or PF3758309 (Selleckchem). siRNA and CRISPR/single guide RNA (sgRNA) treatment.

Techniques: Isolation, Control, Derivative Assay, Two Tailed Test, Saline, Microscopy, Staining, Fluorescence, Imaging, Immunofluorescence